Salta Road Trip and Northwest of Argentina

Discover the heart of Northwestern Argentina at your own pace with this unforgettable Salta Road Trip. A self-drive journey is the ideal way to explore the region’s valleys, salt flats, and hidden villages. Whether you’re drawn to the rugged beauty of the Puna or the vineyards of the Calchaquí Valleys, we help you design a trip that is uniquely yours. We specialize in providing the insider knowledge and local support you need to explore the Northwest with confidence. Our goal is to act as your expert co-pilots: designing a route tailored to your interests while offering dedicated advice before and during your road trip.
For more curated journeys, visit our Argentina Road Trips page.
If you want more tours in Northern Argentina, check out our Northwest Argentina Holidays. But if you'd like to see all of our tours, visit our Argentina Custom Tours!
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Day-by-Day Itinerary
Salta
Welcome to Northwestern Argentina! Upon arrival at Salta Airport, you’ll pick up your rental vehicle and begin the short scenic drive to your selected accommodation. Take the rest of the day to settle in and explore the city at your own pace. We recommend visiting the historic MAAM Museum, taking the scenic cable car to Cerro San Bernardo, or admiring the colonial architecture surrounding Plaza 9 de Julio. For a more active afternoon, the nearby Quebrada de San Lorenzo offers peaceful trails through the lush yungas forest.Salta - Cafayate
Get ready to begin your self-drive journey through the Calchaquí Valleys. Leaving Salta behind, the route takes you into the heart of Quebrada de las Conchas, where millions of years of erosion have sculpted the mountains into surreal red and orange formations. Along the way, admire natural landmarks such as the Amphitheater and the Devil’s Throat before continuing to Cafayate. The day concludes among vineyards with a tasting of the region’s renowned high-altitude wines.Cafayate - Cachi
Following the legendary Route 40, your journey continues north from Cafayate toward Cachi. The landscape changes dramatically as you enter the Quebrada de las Flechas, a spectacular canyon where sharp rock formations rise toward the sky like a giant stone forest. The drive continues through the heart of the Calchaquí Valleys, passing historic villages and remarkable high-altitude desert scenery. By the end of the day, you’ll arrive in Cachi, a charming colonial town known for its whitewashed adobe buildings, cobblestone streets, and the snow-capped Nevado de Cachi towering in the background.Cachi
We’ve left this day free for you to fully enjoy the colonial atmosphere and peaceful beauty of Cachi. If you’re looking for a more active experience, we highly recommend the Cuevas de Acsibi trek. This off-road adventure takes you into a hidden canyon of deep red sandstone, revealing a spectacular natural cathedral of rock that remains one of the region’s best-kept secrets.Cachi - Salta
Leaving Cachi behind, your route crosses Los Cardones National Park, a high-altitude plateau covered with thousands of giant cacti standing like silent sentinels. One of the highlights of the day is the descent along Cuesta del Obispo, a winding mountain road with breathtaking views over the valley below. By evening, you’ll return to Salta for a well-deserved night of rest.Salta - Purmamarca
It’s time to head to the clouds! Ascend the winding Cuesta de Lipán, climbing above 4,000 meters above sea level before descending into the dazzling white expanse of the Salinas Grandes salt flats. On your way back down, arrive in the magical village of Purmamarca, nestled beneath the iconic Hill of Seven Colors. Spend the remainder of the day browsing the local artisan market or strolling along the vibrant Paseo de los Colorados before enjoying a relaxing evening in the heart of the village.Purmamarca
Continue your Salta Road Trip through the Quebrada de Humahuaca, a UNESCO World Heritage Site filled with ancient multicolored villages and remarkable landscapes. Visit the historic ruins of Tilcara and the colonial church of Uquía before continuing to the vibrant town of Humahuaca. From there, ascend to the breathtaking Serranías del Hornocal, also known as the 14-Colored Mountain, where you’ll witness its jagged rainbow-hued peaks at their most spectacular. After taking in the scenery, return to your accommodation in Purmamarca.Purmamarca - Salta
When you’re ready to head south, the road leads back toward Salta for one final evening in the region. You’ll spend the night in the peaceful countryside, allowing you to enjoy a relaxing conclusion to your journey away from the bustle of the city center.Salta OUT
Your Northwestern Argentina road trip comes to an end today. Make your way to the airport to return your rental vehicle before boarding your departing flight.
Where to Stay
Some places where you could stay, from unique premium lodges to classic accommodations.
Grace Cafayate Hotel: An Enchanting Retreat in The NorthwestGrace Cafayate Hotel is located near Cafayate, in Salta Province, at the heart of Argentina’s spectacular Calchaquí Valleys. This remarkable region of northwestern Argentina is known for its…
Patios de Cafayate: Exquisite Elegance in the VineyardsSet against the breathtaking Calchaquí Valleys and surrounded by vineyards, Patios de Cafayate is a charming boutique hotel in Salta, Argentina. Housed in a beautifully restored 19th-century…
Manantial del Silencio Hotel: Serenity in the Heart of the QuebradaManantial del Silencio Hotel is a peaceful boutique hotel in Purmamarca, nestled among the colorful landscapes of the Quebrada de Humahuaca in northern Argentina. Meaning “Spring of Silence,” its name…
Estancia Colomé: Remote Luxury in Argentina’s High-Altitude Wine CountryLocated in the Calchaquí Valleys of Salta, at 2,300 meters (7,500 feet) above sea level, Estancia Colomé is one of Argentina’s most unique high-altitude wine lodges. Part of the renowned Bodega Colomé…
House of Jasmines: A Beautiful Countryside Retreat in SaltaJust a short drive from Salta city, yet a world away in atmosphere, House of Jasmines is a refined and romantic luxury estancia in Salta, nestled at the foot of the Andes. Set within a 100-hectare…
Legado Mítico Salta: Charming Boutique Hotel & Cultural HeritageSet in a beautifully restored historic mansion, once the home of a prominent Salta family, Legado Mítico Salta is a charming boutique hotel in Salta city’s historic center. With just 11 themed…
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